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The impact of these changes on efficacy and safety outcomes remains unknown and should be investigated by clinical studies

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If you are new to self-injection, the overview of peptide injections provides foundational knowledge that applies to semaglutide and all other subcutaneous peptides

Clinical trials of semaglutide, including the SUSTAIN programme, did not show a signal of increased depression in adverse event reporting compared to placebo or active comparators

For comparison, the modified GHRH analog CJC-1295 (specifically the version without DAC, which is what is commonly used in modern clinics) has a longer functional duration that keeps the GHRH stimulus present long enough for a more meaningful, sustained growth hormone pulse to occur