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Despite the multiple studies about various multimodal pharmacological and psychological treatments of depression, the evidence for the efficacy and tolerability of these treatment options remains insufficient ( The delayed, and in many cases poor, response to the current antidepressants may suggest that there are more neurotransmitters involved in the pathophysiology of depression than those accounted for by the monoamine theory

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It also helps the body produce red blood cells and supports overall growth and repair

But if sema does enter the brain cells in humans, then any benefit will include direct actions on the neurons themselves

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