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It directly neutralizes reactive oxygen species (free radicals) before they damage DNA, proteins, and cell membranes
Moreover, WES allows for the integration of pharmacogenomic information, particularly exonic variants in genes related to the Absorption, Distribution, Metabolism, and Excretion (ADME) of drugs, which may complement targeted assays traditionally used to calculate pharmacogenetic profiles, with the possibility of expanding the understanding of gene-drug interactions, and indirectly inform potential drugdrug and drug-nutrient interactionswhich will necessarily have to be calculated through other platforms (Whirl-Carrillo et al., 2012)
For example, a mitoprotection bundle for high-risk surgery might include: a) a sulforaphane-based supplement a day before surgery (to activate Nrf2 antioxidant responses), b) remote ischemic preconditioning during anesthesia induction (209), c) low-dose IL-1ra (anakinra) at start of reperfusion, d) postoperative Dexmedetomidine infusion, and e) high-protein nutrition with omega-3 fatty acids to support recovery
In a third case of MNTI, the patient was followed up after initial therapy for two decades and underwent multiple reconstruction procedures to achieve successful rehabilitation
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