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The retail price of these medications over $1000 per month [57] creates substantial financial barriers for patients and healthcare systems

In humans, the concern is focused on medullary thyroid carcinoma, which is rare and biologically distinct from the more common papillary and follicular thyroid cancers

Curcumin shows enhanced binding affinity for mutant proteins compared to the native form, primarily through increased hydrophobic interactions (Srinivasan and Rajasekaran, 2016)

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