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For type 2 diabetes, NICE guidance (NG28) recommends their use as second- or third-line therapy when metformin alone provides inadequate control, particularly in patients who would benefit from weight loss or where hypoglycaemia risk must be minimised

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all other human data consists of small open-label studies or observational reports from underground fitness communities

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These essential fatty acids provide powerful anti-inflammatory benefits that can significantly impact skin health

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doi:10.1053/cp.1999.v66.100453001

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Any ranking of the two is cross-trial inference, not direct evidence

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