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This is consistent with evidence that odd chain and branched chain fatty acid synthesis is CrAT dependent 38 , and that isoleucine catabolism, a mitochondrial process, can supply propionyl-CoA for histone propionylation and that this correlates with production of propionyl-carnitine 8

Lipid accumulation and expression of genes related to DNL, along with the concomitant induction of aberrant glycolysis, are elevated in the kidneys of patients with fibrosis (Mukhi et al., 2023) and in a mouse model of diabetes