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PMID: 74

Emerging evidence suggests that metformin could improve obesity-induced meta-inflammation via direct and indirect effects on tissue-resident immune cells in metabolic organs (that is, adipose tissue, the gastrointestinal tract and the liver)

Lentinus edodes polysaccharide induces the expression of NRF2 and promotes its binding to antioxidant reactive elements (AREs), which elevates the expression of downstream antioxidant genes and alleviates cisplatin-induced and ROS-mediated nephrotoxicity [27, 208]

Furthermore, the potential health risks associated with combining alcohol and GLP-1 medications, such as hypoglycemia and digestive issues, underscore the importance of moderation and professional guidance

These findings in animal models prompted caution but do not directly predict human outcomes