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Moreover, one phase 2 study conducted by Astrup et al

Mice in NM group received adenine suspension at a dosage of 50 mg/(kgday) by gavage, 0.4 mL/time, once a day for 14 days, and Folium sennae decoction at a dosage of 10 g/(kgday) by gavage, 0.4 mL/time, once a day for 7 days, starting on 8th day

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Step 3: Support the process with cofactors

The B12 addition provides nutritional support that many people on calorie-restricted diets benefit from