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Genetic predisposition Obesity Rapid weight loss, prolonged fasting, and weight cycling Total parenteral nutrition (TPN, ie, all nutrition is derived intravenously) Medications including female hormones and thiazide diuretics (mainly used to treat high blood pressure) Sedentary lifestyle Other diseases and conditions such as metabolic syndrome, celiac disease, and some liver diseases What are the Signs and Symptoms of Gallstones

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According to studies, the reduced incretin effect in patients with T2DM may be due to a decrease in the response of -cell to GIP and/or GLP-1 or a decrease in GLP secretion [15, 18, 27, 28]

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