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Ethical approval All procedures involving animals and their care were approved by the Institutional Animal Care and Use Committee of Jinzhou Medical University (approval number: 20210401001)

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Participants had either a BMI over 30 or a BMI above 27 and at least 1 weight-related complication [2]

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Insulin degludec was administered with a prefilled pen containing 3 mL (U100/mL) daily, titrating weekly starting with 10 U per day