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Its effects on melanocortin pathways also provide insight into appetite regulation and energy homeostasis, making it relevant for broader peptide research

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[8] conducted cDNA analysis of preproglucagon in hamsters, which revealed that mammalian genes differ from those of anglerfish and identified two novel peptides, terming them glucagon-related peptides 1 and 2 (GLP-1, GLP-2)

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The four GLP-1R complexes were prepared for MD simulations with the CHARMM36 force field 58 , employing in-house python htmd 59 and TCL (Tool Command Language) scripts