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Because of its role in cellular energy, NAD+ IV therapy has been explored for benefits such as improved cognitive function, reduced fatigue, and potential anti-aging effects

Lancet Infect Dis 2014;14:982-991

120,122,125,133,134 In addition, insulin signaling is important for synaptic plasticity

These autophosphorylation events and conformational changes create multiple docking sites for a variety of endogenous substrates including members of the insulin receptor substrate (IRS) family which associate with IGF-1R via PTB and SH2 domains, growth receptor binding protein-2 (Grb2) which binds to specific motifs in the IGF-1 receptor as well as in IRS, and the p85 subunit of phosphatidyl inositol-3 kinase (PI3K) which binds to other specific motifs within IRS