Frias JP, Deenadayalan S, et al
The generally accepted calorie deficit for weight loss is 500-750 calories per day, which typically amounts to 10-15% of calories you burn (sources here and here)
"You've got to put some work into it." Erykah Tuakimoana knows that firsthand -- as she's paid more attention to her eating habits and strength training while on a GLP-1 medication
A typical protocol involves daily or near-daily subcutaneous injections during an active cycle, followed by a transition to oral NMN supplementation (typically 250 to 500 mg/day) during the maintenance phase

The answer to this problem is carnitine supplementation because carnitine can help: To maintain activity at the cell level, that fosters the process of fat being turned into energy within the mitochondria (2) To prevent excess accumulation of cellular debris, that is responsible for cell death (3) To support a healthy concentration of nitric oxide, which helps endothelial cells relax and maintain blood flow, supporting proper blood pressure (4) To maintain healthy body fat composition, which in turn supports insulin sensitivity and healthy blood sugar levels already within normal range (5-6) To support brain cells natural defences against age-related memory and cognitive de-cline (7) Serving size: 1 vegetarian capsule Servings per container: 30 Amount per serving: Other ingredients: vegetable cellulose (capsule), dicalcium phosphate, vegetable stearate, silica