Plant Physiol 103:10671073
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Semaglutide is used, along with diet and exercise, to lower blood sugar levels in people with type 2 diabetes mellitus
These changes include basement membrane thickening, pericyte apoptosis, endothelial dysfunction, and subsequent disruption of the blood-retinal barrier (BRB), which collectively contribute to increased vascular permeability and the formation of microaneurysms, the earliest clinically detectable lesions in non-proliferative diabetic retinopathy (NPDR)
Liver glycolysis increases, resulting in an increase in pyruvate and subsequently, by pyruvate dehydrogenase, an increase in acetyl CoA, the substrate for fatty acid synthesis