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The NAA produced in neurons is transported to the cytosol of oligodendrocytes (as well as astrocytes) via the action of the sodium-dicarboxylate cotransporter encoded by the SLC13A3 gene
The synthetic triterpenoid compound bardoxolone methyl (bardoxolone) has also been studied for potential therapeutic applications in various diseases, such as in clinical trials for the treatment of chronic kidney disease, type 2 diabetes, and Alport syndrome [460,461,462,463]
Treatment with a novel selective small molecule inhibitor of G6PD (G6PDi-1) prior to T cell restimulation consequently blocked the production of proatherogenic cytokines TNF and IFN by CD8 + T cells as well as IL-2 and TNF by CD4 + T cells
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