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The isolated fraction induced delta-wave (slow-wave) sleep when injected into recipient animals giving the peptide its name and initiated one of the most distinctive research trajectories in neuropeptide biology: a compound with a clearly demonstrated biological name-property, an exceptionally wide pharmacological activity profile, and nearly five decades later a receptor that remains formally uncharacterised

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224 XieY.BaL.WangM.DengS.ChenS.HuangL.et al (2020)

As the promoters of these genes are high CpG island promoters, this might explain their DNA methylation-free status (Weber et al., 2007