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Results CR has sex-specific effects on body composition and energy balance We randomized 6-month-old male and female 3xTg and non-transgenic (NTg) control mice to one of three groups of equivalent body weight then placed each on one of three dietary regimens: Ad libitum (AL) - mice with free access to a normal rodent diet (Envigo Global 2018

With proper consent, samples were collected from the explanted heart for further comparison to non-failing control heart samples obtained from HOPE

MDA, malondialdehyde

374 Western diet triggers impaired myelin-debris clearance in microglia, thereby impairing lesion recovery after demyelination, which may explain its role in MS induction