Planning a Safe Exit Strategy From GLP-1 Therapy If you decide to stop GLP-1 treatment, gradual tapering is safer than abrupt discontinuation
When examining the data, researchers found that GLP-1RA agents showed potential as adjunctive therapies for psoriasis, particularly for patients with obesity, type 2 diabetes, or cardiometabolic risk
CPT-1 has different isoforms with tissue specific expression, CPT-1A (liver), CPT-1B (muscle), and CPT-1C (brain) [7]
Lanifibranor, a pan-PPAR agonist, achieved MASH resolution without fibrosis worsening in 27% of patients at a 1200 mg dose, and one-stage fibrosis improvement in 26%, along with improvements in insulin sensitivity and fasting glucose levels (131)
In these individuals, it is important to address the underlying cause of this behavior (sometimes it could be untreated mood disorders, eating disorders) with behavioral therapy and appropriate medications