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(2017) Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species

In the treatment of type 2 diabetes , it enhances insulin secretion and inhibits glucagon release , effectively controlling blood sugar levels and improving insulin sensitivity

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So, pharmaceutical companies started investigating the use of GLP-1s for weight-management purposes, and the first GLP-1 weight-loss drug, Saxenda (liraglutide), was approved by FDA in 2014 (it was previously approved to treat diabetes under the name Victoza)