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By analyzing the aortic tissue, we found that FOXO4-DRI treatment significantly increased the expression levels of Ki-67 and Lamin B, while reducing the expression of P21, P16, and -H2AX, similar to the results obtained from naturally aged mice (Figure 2A)

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Multiple Cellular Pathways in Skin Repair Laboratory studies report effects on collagen synthesis, glycosaminoglycan production, MMP-2 expression, TIMP-1 and TIMP-2, and extracellular matrix remodeling in fibroblast or wound-related models [4], [5], [12]

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GHK-Cu builds collagen from the dermal layer up