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The trial endpoints include both traditional AD outcomes (e.g., cognition, brain imaging, AD fluid biomarkers) and gold standard aging measures (e.g., frailty, physical function, epigenetic age, etc.)

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Recent studies have shown that GLP-/GIP dual agonists also have significant lipid-regulating effects

Through its dual agonist effects, tirzepatide leads to significant blood glucose reduction in blood glucose and significant weight loss

This comprehensive approach is what the FDA and medical guidelines call for, but rarely operationalize