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Despite lots of big lingering questions, many clinicians dont think it actually matters right now how GLP-1 interacts with brain receptors on a cellular level, says Laura Huckins, PhD, an associate professor of psychiatry at the Yale School of Medicine

Continuing past week 3 without adjustment

Starting with the lowest dose and extending the intervals between dose increases may improve tolerance, as determined by the prescribing clinician

Losing muscle at that rate can lead to sarcopenia (age-related muscle wasting), weaker grip strength, slower walking, and a greater risk of falls

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