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Current mechanistic understanding emphasizes membrane fluidization and surfactant effects as primary mechanisms at the 180500 mg doses used in tablet formulations, rather than tight junction modulation as previously emphasized (Maher et al., 2009

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The MAPK/ERK signaling cascade primarily mediates cellular proliferation, while the PI3K/AKT pathway predominantly regulates cell survival and apoptosis (Wu et al., 2022)