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This article has been updated with new information from the latest JAMA Cardiology publication

It is frequently accompanied with chronic inflammation over the whole body and is always associated with symptoms that arise from metabolic and vascular alterations [154]

More broadly, the GLP-1 disposal challenge reflects a systemic gap in product stewardship, where responsibility is diffused across patients, pharmacies, municipalities, and manufacturers

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Grace reports that his patients using automated insulin delivery (closed-loop systems that use CGM readings to automatically adjust insulin doses administered by an insulin pump) dont need to do anything