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[35] Long-term potentiation [edit] Long-term potentiation, commonly referred to as LTP, is an increase in synaptic response following potentiating pulses of electrical stimuli that sustains at a level above the baseline response for hours or longer
To this end, Chen et al., has suggested that activation of GLP-1R with liraglutide could protect chondrocytes against endoplasmic reticulum (ER) stress, apoptosis and inflammation by decreasing the release of inflammatory mediators and regulating phosphoinositide 3-kinase (PI3K)/AKT signaling, which suggests that GLP-1R is a therapeutic target for the treatment of OA and that liraglutide could be a therapeutic candidate for clinical application [10]
It is often advisable to start with a lower dose (e.g., one capsule daily) and gradually titrate up to the full dose as tolerated
The NHS follows rules set by NICE (National Institute of Care and Excellence), an independent group that checks which treatments work well and are safe to be used by the NHS
