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Additionally, it is commonly used in the treatment of pernicious anemia , a condition where the bodys ability to absorb B12 from food is impaired

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[6] Chang, C.H., Tsai, W.C., Lin, M.S., Hsu, Y.H., & Pang, J.H.S

Individual results vary based on starting weight, diet quality, activity level, metabolic factors, and dose response

These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism