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MTHFR itself is not linked to reduced life expectancy, but the health risks associated with elevated homocysteinesuch as heart disease and strokecan affect longevity if left unmanaged

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Triple-Hormone-Receptor Agonist Retatrutide for Obesity, Phase 2 trial

In addition, there was no statistically significant difference in the age and gender distribution between the groups, which further enhances the robustness of the study design with regard to issues of age and gender as confounders (Pocock et al

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