CDx Clinical Trials: An Innovative BiomarkerDriven Design to Select Patient Population Upfront Innovative phase Ib biomarker driven selection design to select patient population upfront based on their sensitivity to a drug may help to lower the high attrition rate of new drugs
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A total of 18 differential metabolites were identified, including glycerophosphocholine, deoxyguanosine, thymidine, L-carnitine, carnosine, guanine, pantothenic acid, glycylleucine, oxidized glutathione (GSSG), 1-methylnicotinamide, hypoxanthine, nicotinamide adenine dinucleotide phosphate (NADP), coenzyme Q10, lysine, phenylalanine, guanosine, adenosine, and Gamma-linolenyl carnitine (Table S4)