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This instability can make it difficult to maintain the efficacy of oral NAD+ supplements

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Bauer AZ, Kriebel D, Herbert MR, Bornehag CG, Swan SH

Despite its efficacy, EAs therapeutic use is limited by its diuretic side effects and lack of specificity, prompting the development of derivatives and analogs to improve its selectivity and potency (Tew and Gat, 2001