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In 1986, Nauck et al

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Elevated potassium levels, known as hyperkalemia, must be monitored carefully because, if left unchecked, they can lead to serious complications, including abnormal heart rhythms and, in severe cases, death. Accordingly, it is generally not prescribed to people with certain underlying health conditions, including kidney disease, where the risk of elevated potassium levels is higher, or those with very low blood pressure

Currently, the use of GLP-1 RAs in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) is contraindicated