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These enzymes include: superoxide dismutase glutathione peroxidise glutathione reductase catalases These form the bodys endogenous defence mechanisms to help protect against free radical-induced cell damage

Viceversa, in mice fed a high-fed diet inducing weight gain, hepatic steatosis and IR were accompanied by alterations in expression of hepcidin (a protein that regulates iron homeostasis in response to erythropoietic activity) which preceded dysregulation of iron concentrations particularly in liver and visceral adipose tissue, with no effect on serum iron levels (Varghese et al., 2020)

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Female: Interaction with estrogen-driven tissues