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Combination therapy also modestly improves weight, blood pressure, and lipid parameters, with reductions in body weight of approximately 11.5 kg versus SGLT2i alone, though evidence for additive effects on weight loss is inconsistent

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Ozempic) and chronic weight management (Wegovy)

This is why the compound remains investigational despite three decades of promising animal research

Requirements vary, but generally 1.22.0 g/kg of body weight is recommended