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SARS-CoV-2 spike protein accumulation in the skull-meninges-brain axis: potential implications for long-term neurological complications in post-COVID-19

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GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a small copper-binding tripeptide found naturally in the body

Depletion of beneficial taxa such as Odoribacter (Bacteroidetes) and Lachno Clostridium (Firmicutes), along with increased abundance of pro-inflammatory taxa including Ileibacterium and Olsenella , was associated with reduced SCFA gene expression, downregulation of tight junction proteins (occludin and claudin-1), and microglial activation in the amygdala and arcuate nucleus, indicating gut barrier disruption and neuroinflammation that coincided with anxiety-like behavior

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