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[13] Allergic responses to glycine itself are exceptionally uncommon

A randomized (159), double-blind, placebo-controlled trial involving 46 adult SLE patients (23 in the synbiotic group, 23 in the placebo group) showed that 60 days of synbiotic supplementation significantly increased butyrate metabolism, reduced the pro-inflammatory cytokine IL-6, and inhibited the elevation of hs-CRP

This article covers what the actual evidence supports for each route, and why "bypasses the skin barrier" turns out to be a much smaller part of the real comparison than it first appears

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