Injecting repeatedly into the same area can, over time, lead to lipohypertrophy (hardened fatty tissue), which may reduce absorption efficiency
These changes are likely due in part to glucagon receptor activation, which promotes lipid oxidation and decreases lipogenesis in the liver
The usual doses of Tirzepatide have been tested this way
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Current Problems in Pediatric and Adolescent Health Care, 52 (8), 101241