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When the stomach retains food and digestive juices for extended periods, there is greater opportunity for the lower oesophageal sphincterthe muscular valve separating the stomach from the oesophagusto relax inappropriately or become overwhelmed by increased gastric pressure

This modulatory effect suggests a fundamentally different mechanism and a potentially superior safety profile for cardiovascular applications

Candidiasis Management of fungal infections caused by Candida, commonly affecting the skin or mucous membranes

An ongoing early feasibility trial (ClinicalTrials.gov registration NCT03868670) has recruited participants with treatment-refractory obesity and loss-of-control eating to identify related iEEG activity 23

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