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This means that the dosing question is not just "how much" but "for how long." A researcher who reaches their goal weight at month 8 needs to consider whether to continue at a maintenance dose, reduce to a lower maintenance level, or taper off with the understanding that some regain is likely

Unsurprisingly, not every new AOM asset delivered on those expectations in subsequent phase 2 or phase 3 trials, let alone setting ever more spectacular benchmarks for weight loss, while investors increasingly recognised the importance of a clean tolerability profile alongside compelling efficacy [1]