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Patients also report suffering from side effects like intense nausea and headaches

Different pharmacological trails approved DPP4 inhibitors (Sitagliptin, Saxagliptin and Alogliptin) can be used in patients with CKD or end stage renal disease

40 In patients with T2DM, the SURPASS-2 trial compared tirzepatide with semaglutide 1 mg (both as add-on therapies to metformin) and found tirzepatide was either noninferior or superior at all doses (5 mg, 10 mg 15 mg), for both HbA 1c reduction and weight loss at 40 weeks

Using FDA-approved therapies like tirzepatide and semaglutide with close medical supervision, patients achieve meaningful, sustained weight loss and improved metabolic health

GLP-1s improve insulin sensitivity, helping the body process carbohydrates more efficiently