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It has been used in dermatology for over three decades

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Real-world analysis of post-diagnosis exposure and metastatic progression

Studies have reported low serum folate levels in 15% to 38% of patients with depression and in at least 56% of patients with affective disorders (65)

Patients with coexisting type 2 diabetes and hypertension, or obesity with elevated blood pressure, may derive particular benefit from these additional cardiovascular effects