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Unlike fad diets or over-the-counter supplements, Semaglutide and Tirzepatide are prescription-based treatments provided under professional medical supervision

However, if you are taking the oral version of semaglutide (Rybelsus), it must be taken on an empty stomach 30 minutes before any other oral medications

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Balancing the benefits and harms Compared to basal insulin-based combination therapy, incretin-based combination therapy has the advantage of better HbA1c reduction, significantly lower risk of hypoglycemia, and less frequent injections, especially among long-acting GLP-1 RAs