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tirzepatide trials extended to 72 weeks Population size: Phase 2 trials have smaller participant numbers Protocols: Different study designs and endpoints Reported Adverse Events The 2025 meta-analysis reported on adverse event frequency from the published trial data: The meta-analysis noted that adverse events were more frequent with retatrutide (RR 4.10) compared to tirzepatide (RR 2.78)
The Dual Agonist Breakthrough: Why Two Is Better Than One Tirzepatide, the first dual GLP-1/GIP agonist to reach market, demonstrated that activating both receptors produces superior results to activating GLP-1 alone
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