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Inclusion bodies in ALS induce glutamate neurotransmission, leading to excessive intracellular calcium accumulation and excitotoxicity (Diana and Bongioanni, 2022)
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The results with semaglutide alone are encouraging and suggest a potential new treatment option for a group of patients who previously had very few. Meanwhile, the researchers note that larger clinical trials are needed that focus on patients with cirrhosis to confirm these results
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