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These include: Coronary artery disease Arrhythmias Heart defects occurring from birth Narrowed or blocked blood vessels that may lead to a heart attack or stroke Cardiomyopathy or weak heart muscles All of these conditions and others can lead to damage to heart muscle cells which can then affect the functioning of your heart

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Blood-brain barrier penetration If a peripherally injected peptide is to affect sleep, it must reach the brain

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