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Although the IRE1 inhibitor was inefficient alone, its combination with paclitaxel delayed the time to tumor regrowth after stopping the treatment (Marciniak et al

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Oxid Med Cell Longev 2021(1):6635460 Mathur A, Pandey VK, Kakkar P (2018) Activation of GSK3/-TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy

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Patients should never increase their dose more rapidly than recommended, as this significantly increases the risk of gastrointestinal side effects