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The BMI thresholds are: No underlying health condition: BMI of 35 or higher With an underlying health condition: BMI of 27 or higher, depending on the condition Which Drugs Are Covered
What is Core+
However, in OA, M2 numbers are limited and may shift toward an M1-like phenotype under sustained inflammatory stimuli, reducing their capacity to maintain iron homeostasis (109, 110).Together, these insights support the hypothesis that iron metabolism in M1 macrophages not only contributes to ferroptosis susceptibility in OA, but also represents a potential immunometabolic checkpoint for therapeutic intervention
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