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To determine whether enhanced Gq signaling in cells contributes to improvement of the diabetic state in vivo, we examined the effect of the Gq-specific agonist MK-2305 (10 mg/kg) on glucose tolerance in Kcnj11 / mice and KK-Ay mice

Drug interaction with food and others : Not applicable

Receptor activation G protein signaling starts with the binding of hormone or agonist ligand ( L ) to a receptor on the cell surface (enclosed in the cyan box in Fig

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