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This disulfide bonds reducing function can decrease the viscosity of glycoprotein, thereby reducing sputum viscosity, which explains the role of NAC as a mucolytic agent ( 3 The role of NAC in bone microenvironment 3.1 NAC promotes the osteogenic differentiation of stem cells in the bone immune microenvironment Among the MSCs sourced from various tissues, bone marrow-derived mesenchymal stem cells (BMSCs) and adipose-derived mesenchymal stem cells (AMSCs) are most widely used in bone tissue engineering (Qin et al., 2023)