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12 Neurobiological changes are evident in the premonitory stage and include alterations in nociceptive signalling, while the headache phase involves activation of the trigeminovascular system and, in migraine with aura, a cortical spreading depression-like event characterised by an electrophysiological wave of excitation followed by inhibition in cortical neurons

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10.1016/0024-3205(86)90540-0 Hoshi T, Heinemann S: Regulation of cell function by methionine oxidation and reduction