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Eli Lilly and Company: In the SURMOUNT-5 trial, Lillys weight-loss drug Zepbound showed greater efficacy than Wegovy, achieving 20.2% average weight reduction compared to Wegovys 13.7%, in individuals without diabetes

A.SavonenK.HassinenM.KiviniemiV.et al (2010)

Ghrelin uses Gi2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet -cells: novel signal transduction of ghrelin

However, for around 4% of people, the side effects can be bothersome enough to lead them to stop taking Ozempic

If you take birth control pills, you may need to use additional birth control methods for 4 weeks after starting this medicine, and for 4 weeks each time the dose is raised