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Patients with existing lymphoproliferative disorders require individualised assessment, particularly regarding gastrointestinal side effects and weight loss during cancer treatment

Interestingly, the insulin/IGF-1 pathway displays an antagonistic pleiotropy with aging, i.e., during development insulin/IGF-1 signaling has fundamental functions in cellular differentiation and the growth of animals, whereas later in the life, it regulates metabolism but its activity clearly accelerates the aging process [1, 2]

Archived from the original on 18 January 2017

Amato, A., Baldassano, S., Liotta, R., Serio, R

By reducing appetite, improving metabolism, and stabilizing blood sugar, they make it easier to sustain weight loss over time